Judging Category
Basic or Experimental Research
Student Rank
Senior
College
Sciences and Mathematics
Faculty Sponsor
John C Hershberger jhershberger@astate.edu
Description
In medical and pharmaceutical practices, Biginelli (3,4-dihydropyrimidin-2(1H)-ones) products have a number of potential uses due to their anticancer and anti-inflammatory properties. In addition, they are a possible treatment for acquired immunodeficiency syndrome (AIDS). These compounds can be further modified to exhibit fluorescent properties. However, before using them in medicinal studies, it is useful to establish a procedure that can easily be modified and is synthetically accessible to allow for further optimization. The experiment was performed using the Biginelli compounds as a substrate, along with a variety of aromatic aldehydes and acids. After obtaining the products and purifying them with vacuum filtration and trituration, they were placed under ultraviolet lights to determine if fluorescence was obtained. When applicable, the products also underwent proton nuclear magnetic resonance (NMR) spectroscopy in order to inspect the purity of the isolated compounds. We were able to obtain compounds with fluorescent properties of varying wavelengths. Since Biginelli compounds are already being used for medicinal purposes, giving them fluorescence can help with bioimaging, making it easier to keep track of the fate of these compounds as they are being tested in biological systems.
Disciplines
Organic Chemicals | Organic Chemistry
License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Recommended Citation
Griggs, John R., "Synthesizing Fluorescent 3,4-dihydropyrimidin-2(1H)-ones Using a One-Pot Synthesis Reaction" (2026). Create@State. 27.
https://arch.astate.edu/evn-createstate/2026/posters/27
Included in
Synthesizing Fluorescent 3,4-dihydropyrimidin-2(1H)-ones Using a One-Pot Synthesis Reaction
In medical and pharmaceutical practices, Biginelli (3,4-dihydropyrimidin-2(1H)-ones) products have a number of potential uses due to their anticancer and anti-inflammatory properties. In addition, they are a possible treatment for acquired immunodeficiency syndrome (AIDS). These compounds can be further modified to exhibit fluorescent properties. However, before using them in medicinal studies, it is useful to establish a procedure that can easily be modified and is synthetically accessible to allow for further optimization. The experiment was performed using the Biginelli compounds as a substrate, along with a variety of aromatic aldehydes and acids. After obtaining the products and purifying them with vacuum filtration and trituration, they were placed under ultraviolet lights to determine if fluorescence was obtained. When applicable, the products also underwent proton nuclear magnetic resonance (NMR) spectroscopy in order to inspect the purity of the isolated compounds. We were able to obtain compounds with fluorescent properties of varying wavelengths. Since Biginelli compounds are already being used for medicinal purposes, giving them fluorescence can help with bioimaging, making it easier to keep track of the fate of these compounds as they are being tested in biological systems.
