Date of Award
4-14-2011
Document Type
Thesis
Degree Name
Biology, MS
First Advisor
Ron Johnson
Committee Members
Anne Grippo; Martin Huss
Call Number
LD 251 .A566t 2011 H28
Abstract
Herpes simplex virus-1 (HSV-1) is the source of non-genital herpes infections in humans. The host typically suffers an acute infection followed by latency, in which the host appears asymptomatic as the virus remains present within the host. The virus can reactivate, usually due to physiological stress of the host, which once again becomes symptomatic of herpes. This study examines the role of the reactivation critical region (RCR) by removing a 348-base pair (bp) region transcribing latency-associated transcripts (LAT) from the wild-type HSV-1 strain (17syn+). Upon reactivation, the mice infected with the 17syn+ strain exhibited an 89% reactivation rate while the mutant strain, 17f´348, exhibited a reactivation rate of only 13% in infected mice. The reactivation rates for HSV-1 infected mice were reduced by the manipulation of the RCR, and increased understanding of this region could potentially lead to the reduction of HSV-1 reactivation in an infected host by targeted therapy.
Rights Management
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Hardcastle, Jason, "Reactivation Phenotypes of Parent Strain and Four Viral Constructs in the Murine Hyperthermia Reactivation Model for Herpes simplex virus-1" (2011). Student Theses and Dissertations. 912.
https://arch.astate.edu/all-etd/912
