Date of Award
8-25-2023
Document Type
Thesis
Degree Name
Biology, MS
First Advisor
David Gilmore
Committee Members
Mohammad Alam; Sudeepa Bhattacharyya
Call Number
LD 251 .A566t 2023 A34
Abstract
Melanoma, a fatal type of skin cancer, is still incurable. To develop a possible cure, we synthesized fused thiazole derivatives, and found them to be potent anti-melanoma agents both in vitro and in vivo. Thiazolo ethisterone derivatives were remarkably cytotoxic to melanoma cell lines and inhibited colonization of oncogenic cells. Compounds, in vitro, inhibited three key mechanisms of metastasis; cell migration, adhesion, and invasiveness. The compounds caused mild G2/M phase mitotic cell cycle arrest and induced moderate apoptosis. 3, 4-Dihydroxy substituted thiazolo ethisterone (ET32) upregulated beta-Parvin (PARVB) expression (both mRNA and protein expressions) with a log2 fold change value around two. In a subcutaneous mouse melanoma model, piperazine-substituted thiazolo ethisterone (ET26), ET32, and 3-Fluoro substituted thiazolo androstenone (U3F) retarded tumor growth in male mice, but not in female mice. Serum metabolite profiles of mice indicated that thiazolo ethisterone derivatives were safe to the mice at effective concentrations.
Rights Management
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Adhikary, Sanjay, "Antimelanoma Activities of Fused Thiazole Derivatives" (2023). Student Theses and Dissertations. 162.
https://arch.astate.edu/all-etd/162
