Date of Award
6-12-2025
Document Type
Thesis
Degree Name
Molecular Bioscience, MS
First Advisor
Asela Wijeratne
Committee Members
Fabricio Medina-Bolivar; Sudeepa Bhattacharyya; Tuhin Virmani
Call Number
ISBN 9798280760158
Abstract
Neuropsychiatric symptoms (NPS), such as depression, and anxiety, and mild cognitive impairment (MCI), often precede motor symptoms in Parkinson’s disease (PD), highlighting the need for early biomarkers and mechanistic insights. Gut-microbiome-related metabolites, including secondary bile acids, influence lipid homeostasis and mitochondrial function, impacting neuropsychiatric and neurodegenerative disorders. This study examines metabolic alterations in PD, focusing on lipid metabolism, bile acids, acylcarnitine, and amino acids. Our findings showed significant changes in lipid metabolism, transsulfuration pathway, bile acids, acylcarnitine, and amino acids in PD severity and NPS. Specific lipid subclasses were linked to NPS, cognitive impairment, and motor impairment. Given the limited research on the relationship between olfactory dysfunction, sleep disturbances, and metabolic alterations in PD, this study identifies a critical gap in current knowledge. These results suggest that a multi-omics approach could provide valuable biomarkers for PD progression and symptom severity, emphasizing the need for further validation in larger, longitudinal studies.
Rights Management
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Ratnayake, Raveena Dhanani, "Role Of Gut-Liver-Brain Axis in Neuropsychiatric Symptoms of Parkinson’s Disease" (2025). Student Theses and Dissertations. 1070.
https://arch.astate.edu/all-etd/1070
