Date of Award
9-18-2012
Document Type
Dissertation
Degree Name
Molecular Biosciences, Ph.D.
First Advisor
Roger Buchanan
Committee Members
Alex Biris; Jennifer Bouldin; Scott Reeve; Steve Green
Call Number
LD 251 .A566d 2012 I32
Abstract
With the rapidly expanding field of nanotechnology and the use of nanoparticles, it becomes crucial that science advances in the understanding of the potential associated risks. Inevitably, the increase in use of these particles will result in greater occurrence of exposure. Not only is their relatively small size of concern, but so are the changes in physiochemical characteristics that occur at the nanoscale. A few examples of physical properties that can change as particle sizes become smaller is their color, melting point , optical properties, and solar absorption. While these properties may be beneficial in applications, they can also alter the interactions between particles, the environment and living organisms in unknown ways. This means that nanomaterials must be tested even though the characteristics of the bulk material may be well known. Much work in this field remains to be done and at present science is far from being able to predict these possible interactions. These concerns are the bases for the three projects described herein which investigate the uptake and distribution of two varieties of nanoparticles, quantum dots and carbon nanotubes. Two different routes of exposure, aqueous and inhalation, are also investigated. These exposure routes were selected to mimic likely exposure routes. The models described here are crucial to establishing the foundation for future nanoparticle studies. These models and data presented also provide a critical link between in vivo and in vitro studies that have already been completed and likely scenarios of exposure.
Rights Management
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Ingle, Taylor Michelle, "Characterization of the uptake and Biodistribution of the Nanoparticles Quantum Dots and Carbon Nanotubes" (2012). Student Theses and Dissertations. 885.
https://arch.astate.edu/all-etd/885
