Date of Award
1-7-2013
Document Type
Thesis
Degree Name
Chemistry, MS
First Advisor
Hideya Koizumi
Committee Members
Hashim Ali; Mark Draganjac
Call Number
LD 251 .A566t 2012 Z32
Abstract
Differential mobility analyzer (DMA), coupled with other instrumentation analyzers, such as mass spectrometry (MS), can classify size, masses and shapes by their different gas-phase electrophoretic mobility. In order to obtain the high resolution in classifying large particles (50 kD ~ 1 MD), our laboratory designed several versions of cylindrical cascade type differential mobility analyzers (CTDMA). Because CTDMAs consist of two cylindrical particle classifiers in one housing, target particles are guided through "gaps" and "stairs", a unique feature to this new particle classification device. Two modes of operation--outward cross flow mode and no-cross flow mode--both reduce the flow rate in the exit and excellently improve the detection limit. The software SIMION 8.1, with the user program--Statistical Jump Diffusion (SJD) to satisfy the behavior of larger particles in high pressure, was used to calculate the trajectories and simulate the motion of particles and buffer gas inside the CTDMAs. Lua program is used to control the time-wise change of voltages of electrodes. Suitable complex scan functions are investigated. The simulation results demonstrate the clear separation of mixture and successful gather of identical ions. Our preliminary simulation study predicts much improved performance for new CTDMA over typical settings.
Rights Management
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Zhu, Chenxi, "Preliminary Simulation Study on Classification of Large Molecules by Newly Designed Cascade Type Differential Mobility Analyzer (CTDMA)" (2013). Student Theses and Dissertations. 841.
https://arch.astate.edu/all-etd/841
