Date of Award

12-5-2017

Document Type

Thesis

Degree Name

Engineering, MSE

First Advisor

Brandon Kemp

Committee Members

Malathi Srivatsan; Paul Mixon

Call Number

LD 251 .A566t 2017 S29

Abstract

The purpose of tissue engineering is to regenerate the damaged tissues by using three dimensional porous scaffolds which act as substrates for tissue regeneration. Several studies have showed that structural properties of scaffold (fiber diameter, pore size of scaffold, and fiber orientation) play a significant role in tissue regeneration. Therefore, in order to design a suitable scaffold for tissue engineering application, it is important to understand the structural properties of fibrous scaffold. To achieve this aim in this study, standalone image analysis toolboxes are generated by using the MATLAB software for finding the mean pore size of scaffolds, length, diameter and orientation distribution of fibers from the microscope images. The performance of the developed toolboxes is tested by application to both real fibrous scaffold images and simulated images. The results show that the developed toolboxes are successful in making fast, accurate automated measurements of structural properties of fibrous scaffold.

Rights Management

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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