Date of Award
1-31-2024
Document Type
Thesis
Degree Name
Biology, MS
First Advisor
Guolei Zhou
Committee Members
Jennifer Xie; Jianfeng Xu
Call Number
LD 251 .A566t 2023 R36
Abstract
Cancer is a significant health burden as the second leading cause of death worldwide. Metastasis-driven fatality accentuates the need for novel strategies to impede cancer dissemination. The cytoskeletal protein CAP1 plays a pivotal role in linking cell signals to control the actin cytoskeleton, cell adhesion, and proliferation – critical aspects of both metastasis and proliferative transformation. While the role of CAP1 in the actin cytoskeleton is well elucidated, the CAP1 functions in adhesion and proliferation are cell type-specific with poorly understood molecular mechanisms. This study seeks to unravel how CAP1 executes functions in these processes, aiming to contribute to our understanding of its involvement in cancer, which may open avenues for therapeutic interventions. Our findings revealed a key role for CAP1 in linking the second messenger cAMP to regulate the activities of Rap1 and ERK, leading to cell type-dependent outcomes in matrix adhesion and proliferation of colon and breast cancer cells.
Rights Management
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Ramsey, Auburn, "Dissecting Mechanisms Underlying the Cap1 Functions in the Matrix Adhesion and Proliferation of Cancer Cells" (2024). Student Theses and Dissertations. 132.
https://arch.astate.edu/all-etd/132
