Efficient Synthesis of Thiazole-Fused Bisnoralcohol Derivatives as Potential Therapeutic Agents
Document Type
Article
Publication Title
ACS omega
PubMed ID
38854539
Abstract
Thiazole derivatives are known for a wide range of therapeutic properties. Bisnoralcohol is an inexpensive natural product obtained by the biodegradation of sterols. This article describes an efficient synthesis of a library of thiazole-fused bisnoralcohol derivatives. These novel compounds have been studied for their antineoplastic and antibacterial properties, which led to the discovery of hit compounds with therapeutic potential. The antibacterial compound is noncytotoxic and nonhemolytic against cancer cell lines and sheep red blood cells, respectively. Several of the antineoplastic compounds showed activity against human cancer cell lines with growth inhibition at submicromolar concentration.
First Page
23283
Last Page
23293
DOI
10.1021/acsomega.3c09721
Publication Date
6-4-2024
Recommended Citation
Roy, Subrata; Raj Kc, Hansa; Adhikary, Sanjay; Erickson, Alexander N.; and Alam, Mohammad Abrar, "Efficient Synthesis of Thiazole-Fused Bisnoralcohol Derivatives as Potential Therapeutic Agents" (2024). Arkansas Biosciences Institute. 5.
https://arch.astate.edu/abi/5
